Fig 3.

UPAR protein expression correlates with grade and stage of disease and increases with rate of recurrence and mortality in specimens from patients with adenocarcinoma of the endometrium. An increasing proportion of specimens exhibited a high level of UPAR protein expression in progressing from grade 1 (well differentiated) to grade 3 (poorly differentiated) disease for endometrial adenocarcinoma (a, grouped Spearman correlation = 0.559, P = <0.001) and for patients with endometrioid adenocarcinoma exclusively (b, grouped Spearman correlation = 0.419, P = <0.01). An increased proportion of specimens demonstrates a high UPAR protein expression with advanced stage of disease in patients with endometrial adenocarcinoma (c, grouped Spearman correlation = 0.440, P = <0.0015) and in patients with endometrioid adenocarcinoma exclusively (d, grouped Spearman correlation = 0.324, P = <0.04). UPAR protein expression increases with rate of recurrence and mortality in patients with adenocarcinoma of the endometrium (e).