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. 2025 Oct 6;15:34776. doi: 10.1038/s41598-025-18570-1

Table 7.

Explainability analysis for critical skin lesion classes.

Class Model focus (Grad-CAM) ViT attention focus Clinical relevance
Melanoma Irregular borders, dark pigment clusters High attention to asymmetry and color variegation Aligns with ABCD rule (Asymmetry, Border, Color, Diameter) for malignancy detection
BCC Ulceration, arborizing vessels Focus on shiny white areas and telangiectasia Matches dermoscopic criteria for basal cell carcinoma
Nevi Homogeneous pigment, smooth borders Uniform attention across lesion Consistent with benign features
Vascular Red-blue lacunae, diffuse redness Attention to vascular morphology Correlates with diagnostic patterns in vascular lesions (e.g., lacunar structures)
Dermatofibroma Central white scar-like patch Peripheral network-like structures Reflects hallmark “central white patch” feature used in clinical diagnosis