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Appetite of ob/ob mice treated with angiogenesis inhibitors. Eight-week-old ob/ob mice (n = 4 per group) with free access to chow were treated with (A) TNP-470 (10 mg/kg/day), (B) angiostatin (50 mg/kg/12 h), or (C) endostatin (50 mg/kg per 12 h). We fed the amount consumed per day by each treated mouse to a paired mouse in a second, untreated group (n = 4). We measured body weights of treated, paired-fed, and control mice daily.
