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Bcl-XL-expressing 2B4.11 cells survive in the presence of thapsigargin and have reduced type 1 IP3R mRNA. (A) Survival was measured by propidium iodide exclusion with either 50 nM or 100 nM thapsigargin in the cell cultures at the indicated time points. Means and standard deviations of triplicate measurements are shown. (B) Northern blots of total RNA purified from 2B4.11 Neo and Xl-C10 cells. The filter was hybridized with probes for Bcl-XL, type 1 IP3R, and 18S rRNA, respectively.
