Table 10.
Antigenic site changes in the NA gene from 1977 to 1986
|
|
Amino acid at antigenic site | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| VI | I | II | (VIII) | V | |||||||
| 199 | 332 | 334 | 339 | 342 | 386 | 390 | 392 | 397 | 399 | 434 | |
| USSR/77 | D | K | R | D | N | P | N | L | I | A | K |
| India/80 | D | K | S | D | T | T | N | L | V | A | K |
| Chile/83 | D | K | S | D | T | T | N | L | V | A | K |
| Taiwan/86 | N | E | S | N | T | T | D | S | V | P | N |
Shown are only the antigenic sites in which amino acid changes have occurred, and then only the amino acid positions that have changed are shown; there are actually 46 amino acids in 8 antigenic sites.
*
This antigenic site is not defined as an antigenic site for N2 but it is included here because there are significant changes at this site in the N1 model.