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Aging disrupted the circadian rhythms in RCA and lung. Luminescence of cultured RCA from young (A) and old (B) and from lung of young (D) and old (E) animals are plotted against previous light onset (hour 0). RCA and lung from young rats showed clear circadian oscillations, but RCA and lung from old rats showed weak or no circadian oscillation. Circadian oscillation in old tissue could be induced by forskolin stimulation (arrows) in previously arrhythmic RCA (C) and lung (F).
