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. 2002 Jul 26;99(16):10843–10848. doi: 10.1073/pnas.162228299

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Copyright © 2002, The National Academy of Sciences

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Fig 2. — Clusterin facilitates the conversion of Aβ into amyloid in vivo. The 12-month-old PDAPP^+/+, clusterin^+/+ and PDAPP^+/+, clusterin^−/− mice containing Aβ-immunoreactive deposits were analyzed for the presence of thioflavine-S (Thio-S)-positive plaques (amyloid). (A) Serial brain sections were either immunostained with either a polyclonal antibody against Aβ (Left) or with the dye thioflavine-S (Center and Right). (Scale bars: Left, 500 μm; Center, 250 μm; Right, 125 μm.) (B) PDAPP^+/+, clusterin^−/− mice (n = 15) had significantly less hippocampal thioflavine-S load than littermate PDAPP^+/+, clusterin^+/+ mice (n = 13). *, P = 0.05. (C) The percentage of deposited Aβ that was thioflavine-S-positive (fibrillar) was significantly decreased in PDAPP^+/+, clusterin^−/− mice. **, P < 0.0001. Data in B and C are means ± SEM.