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. 2025 Oct 7;26:923. doi: 10.1186/s12891-025-08938-9

Table 2.

Key clinical differences between septic arthritis and adult-onset Still's disease (AOSD) in the context of postoperative fever—emphasizing diagnostic pitfalls and distinguishing features

Clinical features Septic arthritis AOSD
Fever Most cases are mild and only 30%–40% of individuals have a temperature > 39℃ Peak fever and the highest temperatures (> 39 ℃) occurs at night
Arthralgia and arthritis Most cases are monoarticular and only 10%−20% of individuals have a polyarticular disease Most cases are polyarthritis
Dermatologic manifestations Erythema around the affected joint A macular or maculopapular evanescent salmon-pink skin rash appears together with the fever spikes
Pharyngalgia Generally, not present, but can occur when accompanied by throat infections It occurs before or during the first month of each disease flare
Others Occur rarely but shivering can occur It is common and includes myalgia, enlargement of the lymph nodes, splenomegaly, hepatomegaly, pleurisy, pericarditis, weight loss, etc