Table 2.

Prevalence of adverse events (AEs) related to the use of direct-acting antivirals in the study group according to the participants’ age

Symptom	All participants (n = 165)	Young children (n = 35)	Older children (n = 130)	p
Number of children with any AE*	74 (45%)	16 (46%)	58 (45%)	NS
Abdominal pain	17 (10%)	6 (17%)	9 (7%)	NS
Fatigue/asthenia	16 (10%)	1 (3%)	15 (12%)	NS
Headache	14 (8%)	0	14 (11%)	0.04
Diarrhea	10 (6%)	3 (9%)	7 (5%)	NS
Somnolence	9 (5%)	0	9 (7%)	NS
Pruritus	7 (4%)	2 (6%)	5 (4%)	NS
Vomiting	7 (4%)	3 (9%)	4 (3%)	NS
Rash	7 (4%)	3 (9%)	4 (3%)	NS
Nausea	3 (2%)	0	3 (2%)	NS
Dizziness	3 (2%)	0	3 (2%)	NS
Epistaxis	3 (2%)	2 (6%)	1 (1%)	NS
Other**	7 (4%)	0	7 (5%)	NS

^*There were children who reported more than one AE

NS nonsignificant (p ≥ 0.05)

^**Include the following AEs that occurred in no more than two children: syncope, hair loss, calf cramps, abnormal taste, and chest pain