Table 6.

Antibody-conjugated polymersomes for brain cancer treatment

Type of polymer used	Antibody conjugated + target receptor	Encapsulated compound	Size	Charge	Outcomes (in vitro)	Outcomes (in vivo)	Reference
Poly(2-(diisopropylamino)ethyl methacrylate) (PDPA)	Cys-Angiopep and Cys-RVG targeting LRP-1 receptor expressed by BBB endothelial cells	IgG	100 nm	-	-Enhanced drug delivery across the BBB with Angiopep-2-functionalized nanoparticle (LRP-1 mediated transcytosis) -Increased cellular uptake by bEnd.3 cells with antibody-conjugated nanoparticle compared to control group	-LRP-1 enhances pH-sensitivity of polymersomes to promote drug release in acidic tumor microenvironment	[128]
Methoxy poly(ethylene glycol) (mPEG) and poly(d, l-lactide) (PDLLA)	Anti-epidermal growth factor receptor (anti-EGFR) antibodies targeting EGFR expressed in cancer cells	Acridine orange (AO)	124 nm	-	-AO release from peptide-functionalized polymersome at low pH (5.5) over 3 days at tumor site. However, the release plateaued. -Increased cellular uptake of antibody conjugated polymersomes by SKBR3 cells compared to non-targeted polymersomes	-	[237]