Table 1.
Registered Clinical Trials with hucMSCs-EVs Interventions on Clinicaltrials.gov (http://www.clinicaltrials.gov/)
| NCT Number | Study Title | Conditions | Interventions | Phases | Last Update Posted |
|---|---|---|---|---|---|
| NCT06607900 | HUC-MSC-sEV-001 Nasal Drops for Neurodegenerative Diseases | Alzheimer Disease|Parkinson Disease|Lewy Body Dementia|Multiple System Atrophy|Fronto-temporal Dementia | HucMSCs-EVs | PHASE1 | 2024/9/25 |
| NCT05808400 | Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19 | Long COVID-19 Syndrome | HucMSCs-EVs | EARLY_PHASE1 | 2023/4/14 |
| NCT05787288 | A Clinical Study on Safety and Effectiveness of Mesenchymal Stem Cell Exosomes for the Treatment of COVID-19. | COVID-19 Pneumonia | HucMSCs-EVs | EARLY_PHASE1 | 2023/4/7 |
| NCT04399889 | hCT-MSCs for COVID19 ARDS | COVID|Corona Virus Infection|COVID 19 | HucMSCs-EVs | PHASE1|PHASE2 | 2022/12/20 |
| NCT06813027 | Use of Allogeneic Extracellular Secretomes (EV)Derived from Umbilical Cord Mesenchymal Stromal Cells: a Phase I Open-label Safety Trial. | Vitiligo | HucMSCs-EVs | PHASE1 | 2025/2/6 |
| NCT06431152 | Intra-articular Injection of UC-MSC Exosome in Knee Osteoarthritis | Osteo Arthritis Knee | HucMSCs-EVs | EARLY_PHASE1 | 2024/5/29 |
| NCT06697080 | Umbilical Cord-derived Mesenchymal Stem Cell Exosomes on Hair Growth in Patients with Androgenetic Alopecia | Androgenic Alopecia | HucMSCs-EVs | NA | 2024/11/20 |
| NCT06896747 | Evaluating Mechanically Engineered Stem Cell Exosomes for Treating Endometrial Injury: A Clinical Study | Thin Endometrial Lining|Female Infertility|Intrauterine Adhesions | HucMSCs-EVs | PHASE1|PHASE2 | 2025/3/26 |
| NCT04356300 | Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repair of Acute Type an Aortic Dissection | Multiple Organ Failure | HucMSCs-EVs | NA | 2020/5/6 |
| NCT05871463 | Effect of Mesenchymal Stem Cells-derived Exosomes in Decompensated Liver Cirrhosis | Decompensated Liver Cirrhosis | HucMSCs-EVs | PHASE2 | 2023/5/23 |
| NCT05413148 | The Effect of Stem Cells and Stem Cell Exosomes on Visual Functions in Patients with Retinitis Pigmentosa | Retinitis Pigmentosa | HucMSCs-EVs | PHASE2|PHASE3 | 2022/9/7 |
| NCT06764004 | The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study | Apical Periodontitis | HucMSCs-EVs | PHASE1|PHASE2 | 2025/1/8 |
| NCT06853522 | HucMSCs Exosomes for the Treatment of Active Ulcerative Colitis | Ulcerative Colitis (UC) | HucMSCs-EVs | EARLY_PHASE1 | 2025/3/3 |
| NCT06245746 | UCMSC-Exo for Chemotherapy-induced Myelosuppression in Acute Myeloid Leukemia | Acute Myeloid Leukemia|Neutropenia|Anemia|Thrombocytopenia|Infections|Bleeding | HucMSCs-EVs | PHASE1 | 2025/3/21 |
| NCT06632470 | Clinical Utility and Safety of Human Umbilical Cord Mesenchymal Stem Cell Secretome in Moderate Neurocognitive Impairment (Dementia) | Dementia|Moderate Dementia | HucMSCs-EVs | PHASE1 | 2024/10/9 |
| NCT05777213 | Potential Injection of Human Umbilical Cord Secretome in the Case of Trophic Ulcers (Pre-post Intervention) | Trophic Ulcer; Leprosy | HucMSCs-EVs | PHASE1 | 2023/3/21 |
| NCT06812637 | Efficacy and Safety of Wharton’s Jelly-Derived Mesenchymal Stem Cell Exosomes in the Treatment of Diabetic Foot Ulcers: a Double-blinded Randomized Controlled Clinical Trial | Diabetic Foot Ulcer (DFU) | HucMSCs-EVs | PHASE1 | 2025/2/19 |
| NCT05813379 | Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation | Anti-Aging | HucMSCs-EVs | PHASE1|PHASE2 | 2023/4/14 |
| NCT06629909 | Safety and Feasibility of Human Umbilical Cord Mesenchymal Stem Cell-Derived Secretome in the Treatment of Liver Cirrhosis: a Comprehensive Evaluation of Fibrosis Reduction, Immunomodulation, and Hepatic Regeneration: a Single Center, Randomized, Phase I Clinical Trial | Liver Cirrhosis | HucMSCs-EVs | PHASE1 | 2024/10/8 |
| NCT04213248 | Effect of UMSCs Derived Exosomes on Dry Eye in Patients With cGVHD | Dry Eye | HucMSCs-EVs | PHASE1|PHASE2 | 2022/2/11 |
| NCT06600529 | Combined Photo-Biomodulation at Acupuncture Points, Autologous PRP, and Umbilical Cord-Derived Exosome Therapy in Autism Spectrum Disorder | Autism Spectrum Disorder | HucMSCs-EVs | NA | 2024/9/19 |
| NCT06677931 | Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Melasma | Melasma | HucMSCs-EVs | NA | 2024/11/7 |