Table 2.

Registered Clinical Trials with hucMSCs-EVs Interventions on Irct.behdasht.gov.ir (https://irct.behdasht.gov.ir/)

IRCTID	Study Title	Conditions	Interventions	Phases	Last Update Posted
IRCT20200502047277N1	Safety and Efficacy Assessment of Combination of Artificial Dura and Umbilical Cord and Placenta Mesenchymal Stem Cell-Derived Exosomes in Patients with Acute, Sub-acute and Chronic Complete Spinal Cord Injury: A Single-blinded Controlled Clinical Trial	SCI	HucMSCs-EVs	NA	2023/3/25
IRCT20201202049568N3	Evaluation of the Safety and Efficiency of human Umbilical Cord Derived Mesenchymal Stem Cell Exosomes in patients with ARDS of COVID-19; An interventional randomized double-blind controlled clinical trial: phase I and II	ARDS due to COVID-19	HucMSCs-EVs	PHASE1|PHASE2	2021/3/5
IRCT20160422027520N23	Investigating the effect of intrauterine injection of Extracellular vesicles derived from human umbilical cord Wharton’s Jelly mesenchymal stem cells in the healing process of women with intrauterine adhesions (Asherman syndrome)	Asherman syndrome (intrauterine adhesions)	HucMSCs-EVs	NA	2024/2/21
IRCT20240317061316N1	Evaluation of safety and efficacy of using exosome harvested from human umbilical cord mesenchymal stem cells (hucMSCs) in diabetic foot ulcer patients (Clinical trial Phases I, II)	Diabetic Foot Ulcer	HucMSCs-EVs	PHASE1|PHASE2	2024/7/11