Table 4.
Association of Polymorphisms of Tumor Suppressor TP53 and P21 Genes with Risk of Mucositis after Radiotherapy in Head and Neck Cancer Patients
| Gene /SNP | Genotypes | All Patients | Radiosensitive patients | OR 95% CI | p value |
|---|---|---|---|---|---|
|
TP53
(rs1042522) |
G/G | 133 | 50 | 1 (Reference) | |
| G/C | 70 | 50 | 1.90 (1.16-3.09) | 0.009* | |
| C/C | 47 | 32 | 1.81 (1.04-3.15) | 0.035* | |
| G/C+ C/C | 117 | 82 | 1.86 (1.21-2.86) | 0.004* | |
|
TP53
(rs28934571) |
G/G | 157 | 83 | 1 (Reference) | |
| G/T | 50 | 23 | 0.87 (0.49-1.52) | 0.626 | |
| T/T | 43 | 26 | 1.14 (0.65-1.99) | 0.635 | |
| G/T +T/T | 93 | 49 | 0.99 (0.64-1.54) | 0.987 | |
|
TP21
(rs1801270) |
C/C | 196 | 102 | 1 (Reference) | |
| C/A | 52 | 28 | 1.03 (00.61-1.73) | 0.897 | |
| A/A | 2 | 1 | 0.96 (0.08-10.72) | 0.974 | |
| C/A+ A/A | 54 | 29 | 1.03 (0.61-1.71) | 0.903 | |
|
TP21
(rs1059234) |
C/C | 182 | 94 | 1 (Reference) | |
| C/T | 58 | 33 | 1.10 (0.67-1.80) | 0.701 | |
| T/T | 10 | 5 | 0.96 (0.32-2.91) | 0.954 | |
| C/T+ T/T | 68 | 38 | 1.08 (0.67-1.72) | 0.741 |
SNP, Single nucleotide polymorphism; OR, Odds ratio; CI, Confidence interval; Significance p< 0.05; *, Indicates significant Odds Ratio (p<0.05); p value determined based on χ2.