Table 5.
Association between Genotypes of Tumor Suppressor TP53 and TP21 Genes with Tumor Stage and Tumor Grade in Head and Neck Cancer Patients
| Gene Name (SNP) |
Genotype | Tumor stage | OR 95% CI | p value | Histological Grade | OR 95% CI |
p value | ||
|---|---|---|---|---|---|---|---|---|---|
| T1, T2 n=134 |
T3, T4 n=116 |
I, II n=103 |
III, IV n=147 |
||||||
| TP53 G72C (rs1042522) |
G/G G/C C/C G/C+ C/C |
80 35 19 54 |
53 35 28 63 |
1 (Reference) 1.50 (0.84-2.70) 2.22 (1.12-4.38) 0.76 (1.06-2.91) |
0.166 0.020* 0.027* |
58 30 15 45 |
75 40 32 72 |
1(Reference) 1.03 (0.57-1.84) 1.64 (0.817-3.33) 1.23 (0.74-2.05) |
0.918 0.409 |
| TP53 G249T (rs28934571) |
G/G G/T T/T G/T+ T/T |
85 28 21 49 |
72 22 22 44 |
1 (Reference) 0.92 (0.48-1.76) 1.23 (0.62-2.42) 1.06 (0.63-1.77) |
0.818 0.537 0.823 |
66 20 17 37 |
91 30 26 56 |
1(Reference) 1.08(0.56-2.08) 1.10 (0.55-2.20) 1.09 (0.65-1.85) |
0.799 0.767 0.726 |
| TP21 C98A (rs1801270) |
C/C C/A A/A C/A+ A/A |
106 28 0 28 |
90 24 2 26 |
1 (Reference) 1.00 (0.54-1.86) 5.88 (0.27-124.15) 1.09 (0.59-1.99) |
0.975 0.254 0.771 |
87 14 2 16 |
109 38 0 38 |
1(Reference) 2.16 (1.10-4.25) 0.15 (0.007-3.37) 1.89 (0.99-3.62) |
0.024* 0.238 0.053 |
| TP21 C70T (rs1059234) |
C/C C/T T/T C/T+ T/T |
95 33 6 39 |
87 25 4 29 |
1 (Reference) 0.82 (0.45-1.50) 0.72 (0.19-2.66) 0.81 (0.46-1.42) |
0.532 0.631 0.467 |
73 24 6 30 |
109 34 4 38 |
1 (Reference) 0.94 (0.52-1.73) 0.44 (0.12-1.63) 0.84 (0.48-1.48) |
0.863 0.223 0.566 |
SNP, Single nucleotide polymorphism; CR, Complete Response; PR, Partial Response; NR, No Response; RR, Risk ratio; CI, Confidence interval; Significance p< 0.05; *, Indicates significant Odds Ratio (p<0.05), p value determined based on χ2