Table 6.

Association between Genotypes of Tumor Suppressor TP53 and TP21 Genes with Tumor and Node Response in Head and Neck Cancer Patients towards Radiotherapy

Gene Name (SNP)	Genotype	Tumor Response		Risk Ratio (RR) 95% CI	p value	Node Response		Risk Ratio (RR) 95% CI	p value
		CR	PR/NR			CR	PR/NR
		n=209	n=41			n=217	n=33
TP53 G72C (rs1042522)	G/G	108	25	1 (Reference)		113	20	1(Reference)
	G/C	61	9	0.63 (0.27-1.45)	0.284	61	9	0.83 (0.35-1.94)	0.673
	C/C	40	7	0.75 (0.30-1.88)	0.548	43	4	0.52 (0.16-1.62)	0.264
	G/C+ C/C	101	16	0.68 (0.34-1.35)	0.276	104	13	0.70 (0.33-1.49)	0.361
TP53 G249T (rs28934571)	G/G	130	27	1 (Reference)		134	23	1(Reference)
	G/T	41	9	1.05 (0.45-2.42)	0.896	43	7	0.94 (0.38-2.36)	0.909
	T/T	38	5	0.59 (0.18-1.94)	0.394	40	3	0.43 (0.12-1.53)	0.195
	G/T+ T/T	79	14	0.80 (0.32-2.02)	0.647	83	10	0.70 (0.31-1.54)	0.38
TP21 C98A (rs1801270)	C/C	166	30	1 (Reference)		174	22	1(Reference)
	C/A	41	11	1.48 (0.68-3.20)	0.315	42	10	1.88 (0.82-4.27)	0.13
	A/A	2	0	1.09 (0.05-23.30)	0.955	1	1	7.90 (0.47-130.99)	0.148
	C/A+ A/A	43	11	1.41 (0.65-3.05)	0.375	43	11	2.02 (0.91-4.48)	0.083
TP21 C70T (rs1059234)	C/C	157	25	1 (Reference)		162	20	1 (Reference)
	C/T	43	15	2.19 (1.06-4.51)	0.033*	48	10	1.68 (0.732-3.84)	0.213
	T/T	9	1	0.69 (0.08-5.74)	0.738	7	3	3.47 (0.83-14.50)	0.088
	C/T+ T/T	52	16	1.93 (0.95-3.89)	0.065	55	13	1.91 (0.89-4.10)	0.094

RS, Radiosensitive; SNP, Single nucleotide polymorphism; CR, Complete Response; PR, Partial Response; NR, No Response; RR, Risk ratio; CI, Confidence interval; Significance p< 0.05; *, Indicates significant Odds Ratio (p<0.05); p value determined based on χ²