Table 3.

The median difference (mm³) of the lower face volume after the botulinum toxin injection between each time point (T0, T1, T2, T3)

Area	Volume difference (mm3, median)				p-value*
		T1	T2	T3
Left side	T0	−2,489	−3,632	−2,731	< 0.05
	T1	-	−1,143	−242
	T2	-	-	901
Right side	T0	−3,114	−6,790	−6,253	< 0.01
	T1	-	−3,676	−3,139
	T2	-	-	537
Both sides	T0	−10,540	−7,597	−13,458	< 0.005
	T1	-	2,943	−2,918
	T2	-	-	−5,861

^*p-values represent pairwise comparisons between T0 and subsequent time points (T1, T2, T3). Since all were significant, the least significant p-value is presented for each region. Comparisons among T1, T2, and T3 were not significant and are not shown