TABLE 3.
MICs of erythromycin for mega mutants
| Strain | Em MIC (μg/ml) (±SEM)a
|
|
|---|---|---|
| Etest | Microdilution | |
| GA16638 (type 2 mega, parent) | 15 (±1.00) | 8 |
| GA16638 ΔmefE | 1.13 (±0.16)b | 0.5 |
| GA16638 Δmel | 0.68 (±0.04)b | 0.25 |
| GA16638 ΔmefE Δmel | 0.15 (±0.01)b | 0.06 |
| GA17719 (type 1 mega, parent) | 4.13 (±0.13) | 2 |
| GA17719 ΔmefE | 2.13 (±0.13)b | 0.5 |
| GA17719 Δmel | 0.46 (±0.03)b | 0.25 |
| GA17719 ΔmefE Δmel | 0.13 (±0.00)b | ≤0.03 |
| ATCC 49619 | 0.09 (±0.01)b | ≤0.03 |
a
Standard errors of the means are based on quadruplicate cultures.
b
P < 0.0001 compared to results for the parent strains.