TABLE 1.

Correlations on day 3 of treatment of M. pneumoniae culture, histopathological score, airway obstruction, and airway hyperresponsiveness with cytokine and chemokine concentrations in BAL fluid samples of mice inoculated with M. pneumoniae and treated with LBM415 or placebo^a

Cytokine or chemokine	Mp culture			HPS			AO			AHR			Therapy with LBM415
	r	P	n	r	P	n	r	P	n	r	P	n	r	P	n
TNF-α	0.19	0.441	18	0.72	<0.001	18	0.86	<0.001	16	0.45	0.073	16	−0.80	<0.001	18
IFN-γ	0.12	0.615	18	0.81	<0.001	18	0.83	<0.001	16	0.79	<0.001	16	−0.71	<0.001	18
IL-6	0.02	0.915	18	0.71	<0.001	18	0.90	<0.001	16	0.73	<0.001	16	−0.80	<0.001	18
IL-12	0.13	0.574	18	0.57	0.011	18	0.74	<0.001	16	0.46	0.067	16	−0.50	0.033	18
KC	0.28	0.258	17	0.46	0.059	17	0.59	0.019	15	0.22	0.410	15	−0.62	0.007	17
MIP-1α	0.25	0.307	17	0.67	0.002	17	0.80	<0.001	15	0.52	0.046	15	−0.79	<0.001	17
MCP-1	0.23	0.361	17	0.59	0.012	17	0.77	<0.001	15	0.51	0.046	15	−0.84	<0.001	17
MIG	0.08	0.737	17	0.67	0.002	17	0.83	<0.001	15	0.52	0.044	15	−0.84	<0.001	17
IP-10	0.06	0.797	16	0.59	0.015	16	0.77	<0.001	14	0.56	0.033	14	−0.83	<0.001	16

^aAbbreviations: Mp, M. pneumoniae; AO, airway obstruction; AHR, airway hyperresponsiveness; n, number of mice. Boldface indicates statistically significant values.