TABLE 3.
PRR at 48 h and treatment failure rates in relation to multiple mutations in Pvdhfr and Pvdhps
| Gene(s) | Median PRR at 48 h (range)
|
P valuea | No. of treatment failures/total (%)
|
P valueb | ||
|---|---|---|---|---|---|---|
| ≥4 Pvdhfr mutations, 2 Pvdhps mutations | <4 Pvdhfr mutations, <2 Pvdhps mutations | ≥4 Pvdhfr mutations, 2 Pvdhps mutations | <4 Pvdhfr mutations, <2 Pvdhps mutations | |||
| Pvdhfr | 2.5 (0.3-29) | 13 (2-1,500) | 0.003 | 6/11 (55) | 5/21 (24) | 0.123 |
| Pvdhps | 8.8 (0.33-1,500) | 11.2 (2-1,500) | 0.637 | 6/16 (38) | 5/16 (31) | 0.710 |
| Both | 2.5 (0.3-29) | 12.3 (2-1,500) | 0.013 | 6/9 (67) | 5/23 (22) | 0.035 |
a
Determined by Kruskal-Wallis test.
b
Determined by Fisher's exact test.