TABLE 1.

Bayesian estimated pharmacokinetic parameters derived from the population PK model

Cohort and parameter	Wt (g)	Gestational age (wk)	Anti-SdrG					Anti-ClfA
			V1 (ml/kg)	Vss (ml/kg)	CL (ml/h/kg)	t1/2βa (h)	t1/2αb (h)	V1 (ml/kg)	Vss (ml/kg)	CL (ml/h/kg)	t1/2β (h)	t1/2α (h)
500 mg/kg
Avg	858	27.7	79	218	0.25	644	14.1	72	193	0.22	641	12.7
SD	160	2.2	10	28	0.05	134	1.8	20	53	0.04	119	0.1
750 mg/kg
Avg	837	26.6	79	162	0.26	633	14.1	75	201	0.22	651	12.7
SD	198	1.2	9	79	0.07	168	1.6	28	75	0.05	143	0.1

^at_1/2β, elimination half-life.

^bt_1/2α, distribution half-life.