TABLE 2.
Characteristics of INH-resistant M. tuberculosis isolates
| Strain no. | Resistance pattern | MIRU-ETRa | Genetic groupb | Country of birth | Mutation identifiedc |
|---|---|---|---|---|---|
| 2285 | INH, RIF | 424 221325173433 | 1 M | South Korea | D117A |
| 2316 | INH | 424 223325173533 | 1 M | Vietnam | S315T |
| 2357 | INH, ETH | 464 254226223433 | 1 A | Philippines | −15C→T |
| 2370 | INH, STR | 324 224125113322 | 2/3 | Ethiopia | S315T |
| 2376 | INHI | 622 226425133533 | 1 M | Sudan | −15C→T |
| 2377 | INH | 464 274326223632 | 1 A | Philippines | S315T |
| 2381 | INH | 323 226325153321 | 2/3 | Indonesia | S315T |
| 2382 | INH | 224 223226153321 | 2/3 | Somalia | S315T |
| 2405 | INHI, ETH, RIF, STR | 424 223315173533 | 1 M | Vietnam | −15C→T |
| 2413 | INH, STR | 424 222325173543 | 1 M | Vietnam | S315T |
| 2458 | INHI, STR | 424 223325173633 | 1 M | Vietnam | −15C→T |
| 2475 | INH | 424 223325163533 | 1 M | Vietnam | S315T |
| 2482 | INH, EMB | 614 274326223434 | 1 A | India | S315T |
| 2492 | INH | 464 254326223432 | 1 A | China | S315T |
| 2498 | INH | 663 254226223522 | 1 A | India | S315T |
| 2501 | INH | 424 223325171431 | 1 M | Vietnam | S315T |
| 2503 | INH, STR | 952 252326223513 | 1 A | Australia | S315T |
| 2523 | INH | 424 223425173542 | 1 M | China | −15C→T |
| 2558 | INH | 422 226525163543 | 1 M | India | −17G→T |
| 2562 | INH | 324 223326152321 | 2/3 | England | G491C |
| 2591 | INH | 424 223425173543 | 1 M | India | S315T |
| 2603 | INHI, ETH | 644 274225223534 | 1 A | Laos | −15C→T |
| 2620 | INHI | 323 225323153323 | 2/3 | Somalia | −15C→T |
| 2628 | INH | 842 254326223523 | 1 A | Indonesia | S315T |
| 2640 | INH, ETH | 464 254326223442 | 1 A | Philippines | −15C→T |
| 2643 | INH, EMB, PZA, RIF | 424 223325173533 | 1 M | Korea | S315T |
| 2683 | INH | 422 226525153543 | 1 M | India | S315T |
| 2779 | INH | 424 223326171531 | 1 M | Vietnam | S315T |
| 2783 | INH, STR | 023 223125173533 | 1 M | China | S315T |
| 2786 | INH, STR | 424 223325173532 | 1 M | Australia | S315T |
| 2790 | INHI, STR | 323 225325153323 | 2/3 | India | −15C→T |
| 2802 | INH, STR | 424 242325152322 | 2/3 | Vietnam | S315T |
| 2803 | INH, STR | 424 223325143533 | 1 M | Vietnam | S315T |
| 2807 | INH | 744 263225223532 | 1 A | Australia | S315T |
| 2813 | INH, PZA, STR | 744 394226233533 | 1 A | Vietnam | S315T |
| 2817 | INH, STR | 635 228225123433 | 1 M | Vietnam | −15C→T |
| 2847 | INHI | 464 254326223432 | 1 A | Philippines | −15C→T |
| 2868 | INH, STR | 744 394225223533 | 1 A | Vietnam | S315T |
| 2873 | INH, PZA, STR | 424 223326171533 | 1 M | Vietnam | S315T |
| 2896 | INH | 744 364225223534 | 1 A | Vietnam | S315T |
| 2899 | INH, STR | 422 224425173533 | 1 M | India | S315T |
| 2908 | INH, PZA, STR | 024 242325132322 | 2/3 | Vietnam | S315T |
| 2919 | INHI | 024 242325152322 | 2/3 | Australia | ND |
| 2927 | INHI, STR | 424 222325163553 | 1 M | PNGd | −15C→T |
| 2938 | INHI, STR | 422 246425163534 | 1 M | Sudan | M2571 |
| 2951 | INH | 544 284225223533 | 1 A | Cambodia | S315T |
| 2956 | INH, ETH | 422 225425143533 | 1 M | India | ND |
| 2960 | INH, PZA, RIF, STR | 422 225425133533 | 1 M | China | S315T |
| 2966 | INH, STR | 422 227425113434 | 1 M | Eritrea | S315T |
| 2974 | INH, RIF, STR | 424 223315153321 | 2/3 | Vietnam | S315T |
| 2999 | INH, STR | 324 225125113322 | 2/3 | Ethiopia | S315T |
| 3015 | INH | 952 353326223513 | 1 A | Zambia | S315T |
Number of repeats at variable-number tandem repeat-ETR loci A, B, and C and MIRU loci 2, 4, 10, 16, 20, 23, 24, 26, 27, 31, 39, and 40, respectively.
According to the scheme described by Sreevatsan et al. (28), genetic group 1 includes katG463 CTG (Leu) and genetic groups 2/3 include katG463 CGG (Arg). According to the scheme described by Sun el al. (29), A represents ancestral (> 1 repeat at MIRU 24) and M represents modern (1 repeat at MIRU 24).
D117A, katG117 GAC (Asp) to GCC (Ala); S315T, katG315 AGC (Ser) to ACC (Thr); −15C→T, cytosine-to-thymine substitution 15 bases upstream of fabG1 start codon; −17G→T, guanine-to-thymine substitution 17 bases upstream of fabG1 start codon; G491C, katG491 GGC (Gly) to TGC (Cys); M257I, katG257 ATG (Met) to TGC (Ile); ND, not detected.
PNG, Papua New Guinea.