TABLE 1.

Activities of doripenem and comparator agents^a

Organism (nb) and antimicrobial agent	MIC50	MIC90	Geometric mean MIC	Range	%S	%I	%R
B. fragilis (81)
Doripenem (116)c	0.5	1	0.5	0.25-16	96	3	1
Ertapenem	0.25	0.5	0.3	0.12-4	100	0	0
Imipenem	0.25	0.5	0.2	0.06-2	100	0	0
Meropenem	0.12	0.5	0.2	0.12-8	97	3	0
Ceftriaxone	32	>32	25.7	8->32	15	48	37
Levofloxacin	2	2	1.5	0.50-8	91	5	4
B. ovatus (20)
Doripenem (27)	0.5	1	0.4	0.12-2	100	0	0
Ertapenem	0.5	1	0.5	0.12-2	100	0	0
Imipenem	0.25	0.5	0.2	0.06-0.50	100	0	0
Meropenem	0.25	0.5	0.2	0.03-0.50	100	0	0
Ceftriaxone	32	>32	25	8->32	20	50	30
Levofloxacin	8	16	7.5	4-16	0	25	75
B. thetaiotaomicron (42)
Doripenem (44)	0.5	1	0.6	0.12-2	100	0	0
Ertapenem	0.5	2	0.6	0.06-2	100	0	0
Imipenem	0.5	1	0.4	0.03-1	100	0	0
Meropenem	0.25	0.5	0.3	0.06-1	100	0	0
Ceftriaxone	32	>32	31.1	16->32	2	58	40
Levofloxacin	8	8	6.3	1->32	2	29	69
Other B. fragilis grp. species (23)
Doripenem (39)	0.5	2	0.6	0.12-16	98	0	2
Ertapenem	0.5	2	0.6	0.12-2	100	0	0
Imipenem	0.5	1	0.4	0.03-1	100	0	0
Meropenem	0.25	0.5	0.3	0.06-1	100	0	0
Ceftriaxone	32	>32	30.3	16->32	4	53	43
Levofloxacin	2	16	3.9	1-32	52	13	35
Bilophila wadsworthia (21)
Doripenem	0.12	0.12	0.1	0.03-0.12	100	0	0
Ertapenem	0.12	0.12	0.1	0.03-0.12	100	0	0
Imipenem	0.12	0.25	0.1	0.06-0.25	100	0	0
Meropenem	0.062	0.12	0.1	0.03-0.12	100	0	0
Ceftriaxone	>32	>32	13.4	0.03->32	10	47	43
Levofloxacin	1	4	1.1	0.25-16	86	9	5
Fusobacterium species (15)
Doripenem	0.031	1	0.1	0.03-1	100	0	0
Ertapenem	0.031	1	0	0.03->32	93	0	7
Imipenem	0.12	1	0.1	0.03-2	100	0	0
Meropenem	0.031	0.12	0	0.03-0.50	100	0	0
Ceftriaxone	0.5	32	0.6	0.06->32	87	6	7
Levofloxacin	1	1	0.8	0.25-1	100	0	0
Porphyromonas species (20)
Doripenem	0.031	0.5	0.1	0.03-4	100	0	0
Ertapenem	0.031	0.5	0.1	0.03-32	95	0	5
Imipenem	0.031	0.12	0.1	0.03-1	100	0	0
Meropenem	0.031	0.5	0.1	0.03-8	95	5	0
Ceftriaxone	0.12	1	0.2	0.03->32	95	0	5
Levofloxacin	0.25	1	0.4	0.06-2	100	0	0
Prevotella oris/buccae (10)
Doripenem	0.12	0.5	0.2	0.03-0.50	100	0	0
Ertapenem	0.12	0.25	0.2	0.06-0.50	100	0	0
Imipenem	0.062	0.25	0.1	0.03-0.50	100	0	0
Meropenem	0.12	0.25	0.1	0.03-0.25	100	0	0
Ceftriaxone	8	>32	3.3	0.50->32	50	20	30
Levofloxacin	1	1	1.1	0.50-4	90	10	0
Prevotella bivia and disiens (15)
Doripenem	0.12	0.5	0.1	0.03-4	100	0	0
Ertapenem	0.25	0.5	0.2	0.03-1	100	0	0
Imipenem	0.062	0.25	0.1	0.03-2	100	0	0
Meropenem	0.12	0.5	0.1	0.03-2	100	0	0
Ceftriaxone	2	32	1.9	0.12->32	87	6	7
Levofloxacin	1	8	1.4	0.25-8	73	7	20
Prevotella intermedia/nigrescens (10)
Doripenem	0.031	0.062	0	0.03-0.06	100	0	0
Ertapenem	0.031	0.062	0	0.03-0.06	100	0	0
Imipenem	0.031	0.031	0	0.03-0.03	100	0	0
Meropenem	0.062	0.062	0.1	0.03-0.06	100	0	0
Ceftriaxone	0.12	4	0.3	0.03-8	100	0	0
Levofloxacin	0.5	0.5	0.5	0.50-0.50	100	0	0
Other Prevotella species (22)
Doripenem	0.062	0.12	0.1	0.03-0.25	100	0	0
Ertapenem	0.062	0.25	0.1	0.03-0.25	100	0	0
Imipenem	0.031	0.062	0	0.03-0.12	100	0	0
Meropenem	0.062	0.25	0.1	0.03-0.25	100	0	0
Ceftriaxone	0.25	16	0.4	0.06->32	95	0	5
Levofloxacin	1	1	0.9	0.50-1	100	0	0
Sutterella wadsworthensis (12)
Doripenem	4	8	2.3	0.06-32	73	18	9
Ertapenem	0.5	1	0.3	0.03-1	100	0	0
Imipenem	1	4	1.2	0.03-16	91	0	9
Meropenem	4	4	1.1	0.03->32	92	0	8
Ceftriaxone	>32	>32	3.2	0.25->32	25	0	75
Levofloxacin	0.5	2	0.7	0.25-2	100	0	0
Clostridium species (25)
Doripenem	1	2	0.5	0.03-4	100	0	0
Ertapenem	2	8	0.8	0.03-8	84	16	0
Imipenem	2	8	0.9	0.03-8	80	20	0
Meropenem	1	2	0.5	0.03-4	100	0	0
Ceftriaxone	8	32	5.3	0.25->32	72	24	4
Levofloxacin	4	32	4	0.25-32	28	28	44
Anaerobic gram-positive cocci (18)
Doripenem	0.031	0.12	0	0.03-0.25	100	0	0
Ertapenem	0.031	0.25	0.1	0.03-0.25	100	0	0
Imipenem	0.062	0.062	0	0.03-0.12	100	0	0
Meropenem	0.031	0.12	0	0.03-0.12	100	0	0
Ceftriaxone	0.25	4	0.4	0.12-4	100	0	0
Levofloxacin	0.5	2	0.5	0.25-8	95	0	5
Nonsporing gram-positive rods (30)
Doripenem	0.12	0.25	0.2	0.03-8	97	3	0
Ertapenem	0.12	0.5	0.2	0.03-16	97	0	3
Imipenem	0.12	0.25	0.1	0.03-1	100	0	0
Meropenem	0.062	0.25	0.1	0.03-8	97	3	0
Ceftriaxone	0.25	0.5	0.2	0.06-16	100	0	0
Levofloxacin	2	8	1.7	0.25-32	80	7	13
Total (364)
Doripenem (424)	0.25	1	0.3	0.03-32	98	1	1
Ertapenem	0.25	1	0.2	0.03->32	98	1	1
Imipenem	0.12	1	0.2	0.03-16	98	2	0
Meropenem	0.12	0.5	0.2	0.03->32	99	1	0
Ceftriaxone	32	>32	3	0.03->32	47	29	24
Levofloxacin	1	8	1.7	0.06->32	69	11	20

^a%S, %I, and %R, percentage of isolates susceptible, intermediate, or resistant, respectively; grp., group. Susceptible (intermediate) breakpoints used were as follows: for ertapenem, imipenem, and meropenem, 4 (8) μg/ml; and for ceftriaxone, 16 (32) μg/ml. Doripenem does not have a CLSI-approved breakpoint, and a tentative breakpoint of 4 (8) μg/ml was used to facilitate comparison with the other carbapenems. A tentative breakpoint of 2 (4) μg/ml was used for levofloxacin, which also does not have a CLSI-approved breakpoint.

^bNo. of isolates.

^cNo. of isolates tested with doripenem.