TABLE 2.
Once-a-week 6-month treatment of tuberculosis in mice: CFU counts in lungs
| Group (description)a | Lung CFU count (log10)
|
Proportion of miceb with positive lung culture at 9 mo | ||||
|---|---|---|---|---|---|---|
| D − 13 | D0 | 2 wk | 2 mo | 6 mo | ||
| 1 (controls) | 4.04 ± 0.07 | 5.57 ± 0.40 | ||||
| 2 (2 mo RHZ + 4 mo RH 5/7) | 1.8 ± 0.31 | 0 | 0/18 (0) | |||
| 3 (2 wk RHZM100 5/7 + 5.5 mo P10HM100 1/7) | 4.17 ± 0.18 | 0 | 4/15 (27) | |||
| 4 (2 wk RHZM400 5/7 + 5.5 mo P10HM400 1/7) | 3.86 ± 0.27 | 0 | 0/16 (0) | |||
| 5 (2 wk RHZM100 5/7 + 5.5 mo P15HM100 1/7) | 0 | 2/16 (13) | ||||
| 6 (2 wk RHZM400 5/7 + 5.5 mo P15HM400 1/7) | 0 | 0/13 (0) | ||||
| 7 (6 mo HP15M400 1/7) | 0 | 2/18 (11) | ||||
a
Abbreviations used in this table are the same as those used in Table 1.
b
No. with positive culture / no. studied (%).