TABLE 1.
Potencies of veterinary fluoroquinolones expressed in terms of MICs and MPCsa
| Compound |
E. coli ATCC 8739
|
S. aureus ATCC 6538
|
||||
|---|---|---|---|---|---|---|
| MIC (μg/ml) | MPC (μg/ml) | MPC/MIC | MIC (μg/ml) | MPC (μg/ml) | MPC/MIC | |
| Pradofloxacin | 0.015-0.03++ | 0.2-0.25 | 9.4 | 0.03-0.06++ | 0.5-0.6** | 12 |
| Danofloxacin | 0.06 | 0.5-0.55 | 8.8 | 0.125-0.25 | 10-11* | 56 |
| Difloxacin | 0.125-0.25 | 1.5-1.6 | 8.3 | 0.125 | 16-18* | 136 |
| Enrofloxacin | 0.03-0.06+ | 0.3-0.35 | 7.8 | 0.06-0.125++ | 3-3.5* | 35 |
| Marbofloxacin | 0.03 | 0.25-0.3 | 9.2 | 0.25-0.5 | 3-3.5 | 9 |
| Orbifloxacin | 0.125 | 1-1.25 | 9.0 | 0.5 | 8-9 | 17 |
| Sarafloxacin | 0.03-0.06 | 0.5-0.6 | 12.2 | 0.125-0.25 | 8-9 | 45 |
| Ciprofloxacin | 0.015-0.03 | 0.1-0.15 | 5.6 | 0.25-0.5+ | 6 | 16 |
| Moxifloxacin | 0.06-0.125 | 0.5-0.6 | 6.0 | 0.03-0.06 | 0.8-1 | 20 |
a
MICs have been compiled from three, six, or seven (+) and 10 to 14 (++) independent experiments; the more frequent result is printed in bold. MPCs were determined in three, five (*), or nine (**) experiments. In calculations, mean values were employed.