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Anti-HCV effect of SSG and IFN-α in combination. The synergism, additivity, and antagonism between two drugs were analyzed by traditional isobologram analysis. Isoboles of 50% (EC50; filled circles) and 80% (EC80; open triangles) inhibition of HCV replication by the combination of SSG and IFN-α were shown to indicate that these two drugs exerted a synergistic anti-HCV effect. Each point in the isoboles was derived from calculation of raw data from Table 2.
