TABLE 2.
Effects of combination of SSG and IFN-α on HCV replicationa
| IFN-α concn (IU/ml) | Mean SEAP activity ± SD with a sodium stibogluconate concn (mg/ml) of:
|
||||
|---|---|---|---|---|---|
| 0.00 | 0.03 | 0.13 | 0.50 | 2.00 | |
| 0.00 | 101.7 ± 1.9 | 72.0 ± 6.1 | 70.7 ± 4.0 | 31.6 ± 6.1 | 13.2 ± 2.8 |
| 0.16 | 101.8 ± 7.6 | 67.8 ± 1.6 | 64.9 ± 2.4 | 24.9 ± 2.6 | 12.8 ± 1.7 |
| 0.63 | 75.4 ± 1.0 | 62.0 ± 4.9 | 44.7 ± 2.2 | 22.8 ± 0.8 | 11.5 ± 2.0 |
| 2.50 | 61.8 ± 3.8 | 49.6 ± 4.8 | 26.8 ± 4.2 | 16.5 ± 1.1 | 9.7 ± 3.6 |
| 10.00 | 31.2 ± 1.4 | 26.2 ± 2.4 | 16.4 ± 1.9 | 10.9 ± 1.8 | 9.6 ± 5.5 |
a
Remaining SEAP activities (% of control) are shown. All measurements were performed in triplicate.