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Interaction of SSG with IFN-αa
| IC | CI with the following SSG/IFN-α ratio:
|
|
|---|---|---|
| 1:5 | 1:20 | |
| 50% | 0.60 | 0.60 |
| 75% | 0.55 | 0.39 |
| 90% | 0.52 | 0.26 |
CalcuSyn analysis provides CI values to determine potential drug additivity. The results showed that SSG combined with IFN-α is synergistic, with CI values ranging from 0.32 to 0.60. The CI determines the degree of the interaction of drugs; e.g., CIs of <1, 1, and >1 are indicative of synergistic, additive, and antagonistic effects, respectively.
