TABLE 2.
Frequency of resistant-colony formation in the presence of HCV inhibitors and neomycin
| No. of cells and frequencya | No. of colonies
|
||
|---|---|---|---|
| A-782759 | BILN-2061 | A-782759 + BILN-2061 | |
| 10b | 10 | 5 + 5 10 + 10 | |
| 2 × 104 cells | 123 | 10 | 0 0 |
| 2 × 105 cells | NDc | ND | 21 |
| Frequency (%) | 0.62 | 0.05 | 0.001 0.0005 |
Frequency was calculated using equation: “number of colonies observed / the number of initial cells used × 100”.
Multiple of IC50.
ND, not done.