Table 3. Cadiot–Chodkiewicz coupling reaction-CuAAC sequence to prepare 1,2,3-triazole-containing PAC analogues.
| |||
|---|---|---|---|
| Alkyne | Azide | Product | Yield |
| 3 |
|
|
34% |
| 3 |
|
|
21% |
| 3 |
|
|
2% |
| 5 |
|
|
50% |
| 5 |
|
|
34% |
| 5 |
|
|
4% |
| |||
|---|---|---|---|
| Alkyne | Azide | Product | Yield |
| 3 |
|
|
34% |
| 3 |
|
|
21% |
| 3 |
|
|
2% |
| 5 |
|
|
50% |
| 5 |
|
|
34% |
| 5 |
|
|
4% |