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. 2025 Oct 14;15(45):38307–38320. doi: 10.1039/d5ra06473b

Table 6. C-Desilylation of the dialkynylcarbinol-cored PAC analogues.

graphic file with name d5ra06473b-u43.jpg
Substrate Conditions Product Yield
23 Dry THF + 3% H2O, 1.5 eq. TBAF, 0 °C to RT, 3 h graphic file with name d5ra06473b-u44.jpg 60%
25 Dry THF, 1.3 eq. TBAF, 0 °C to RT, 0.5 h graphic file with name d5ra06473b-u45.jpg 40%
38 Dry THF + 2.5% H2O, 4 eq. TBAF, 0 °C to RT, 24 h graphic file with name d5ra06473b-u46.jpg 54%
44 Dry THF, 1.5 eq. TBAF, −20 °C to 10 °C, 2.5 h graphic file with name d5ra06473b-u47.jpg 42%