Table 6. C-Desilylation of the dialkynylcarbinol-cored PAC analogues.
| |||
|---|---|---|---|
| Substrate | Conditions | Product | Yield |
| 23 | Dry THF + 3% H2O, 1.5 eq. TBAF, 0 °C to RT, 3 h |
|
60% |
| 25 | Dry THF, 1.3 eq. TBAF, 0 °C to RT, 0.5 h |
|
40% |
| 38 | Dry THF + 2.5% H2O, 4 eq. TBAF, 0 °C to RT, 24 h |
|
54% |
| 44 | Dry THF, 1.5 eq. TBAF, −20 °C to 10 °C, 2.5 h |
|
42% |