Table 8. Cell viability data on U2OS WT or KO HSD17B11 (IC50 values in μM). IC50 values on U2OS for the reference compound 6 were reported previously18.
| Compound | WT | KO HSD17B11 | Ratio IC50 KO/WT |
|---|---|---|---|
|
0.08 | >5 | >62.5 |
|
0.33 | 12.0 | 36.3 |
|
1.18 | 8.61 | 7.3 |
|
0.48 | 11.1 | 23.2 |
|
0.24 | 13.9 | 57.8 |
|
1.74 | 7.38 | 4.2 |
|
0.06 | 1.68 | 28.0 |
|
0.15 | 1.34 | 8.9 |
|
0.34 | 1.52 | 4.5 |
|
0.14 | 0.21 | 1.5 |
|
0.97 | 1.08 | 1.1 |
|
0.22 | 0.49 | 2.2 |
|
0.91 | 4.22 | 4.6 |
|
0.21 | >20 | >95.2 |
|
0.07 | 9.18 | 131.1 |
|
0.58 | 4.20 | 7.2 |