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. 2025 Oct 14;15(45):38307–38320. doi: 10.1039/d5ra06473b

Table 8. Cell viability data on U2OS WT or KO HSD17B11 (IC50 values in μM). IC50 values on U2OS for the reference compound 6 were reported previously18.

Compound WT KO HSD17B11 Ratio IC50 KO/WT
graphic file with name d5ra06473b-u74.jpg 0.08 >5 >62.5
graphic file with name d5ra06473b-u75.jpg 0.33 12.0 36.3
graphic file with name d5ra06473b-u76.jpg 1.18 8.61 7.3
graphic file with name d5ra06473b-u77.jpg 0.48 11.1 23.2
graphic file with name d5ra06473b-u78.jpg 0.24 13.9 57.8
graphic file with name d5ra06473b-u79.jpg 1.74 7.38 4.2
graphic file with name d5ra06473b-u80.jpg 0.06 1.68 28.0
graphic file with name d5ra06473b-u81.jpg 0.15 1.34 8.9
graphic file with name d5ra06473b-u82.jpg 0.34 1.52 4.5
graphic file with name d5ra06473b-u83.jpg 0.14 0.21 1.5
graphic file with name d5ra06473b-u84.jpg 0.97 1.08 1.1
graphic file with name d5ra06473b-u85.jpg 0.22 0.49 2.2
graphic file with name d5ra06473b-u86.jpg 0.91 4.22 4.6
graphic file with name d5ra06473b-u87.jpg 0.21 >20 >95.2
graphic file with name d5ra06473b-u88.jpg 0.07 9.18 131.1
graphic file with name d5ra06473b-u89.jpg 0.58 4.20 7.2