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. 2025 Sep 16;647(8091):1063–1071. doi: 10.1038/s41586-025-09610-x

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — a, Composite map of apo hGluD2, with the unsharpened map and Gaussian-filtered map overlaid. b, Surface representation of the hGluD2 structure. c, Slices through each domain presented in b. Flexible regions are outlined with dashed lines. A-ATD, subunit A ATD. d, Overview of features in a single hGluD2 protomer from N terminus to C terminus. e, View of the hGluD2 ion channel composed of helices M2 and M3. Subunit A is omitted for clarity. f, Pore radius profile for apo hGluD2. The dashed line at 1.4 Å represents the radius of a water molecule.