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. 2025 Sep 16;647(8091):1063–1071. doi: 10.1038/s41586-025-09610-x

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Extended Data Fig. 8 — a, Overview of potential contacts (residues within 5 Å of each other) between the A-ATD and A through C LBDs. b, i, 10 s recording of hGluD2_ΔATD currents in response to 10 mM D-serine. ii, the hGluD2_ΔATD current recording overlayed with the hGluD2 D-serine current recording presented in Fig. 2b. c, Histogram of hGluD2_ΔATD currents in the presence of D-serine fit with three components (n = 21 individual traces, R² = 0.9814). Conductance levels ± S.D. corresponding to each gaussian component are labeled above. d, Composite cryoEM map of hGluD2_ΔATD. e, Slice through the local LBD map of hGluD2_ΔATD. f, Slice through the TMD of hGluD2_ΔATD. g, Pore radius profile of hGluD2_ΔATD. The dashed line represents the 1.4 Å radius of a water molecule.