Extended Data Fig. 12. hGluD2_R710W map quality and patient mutations in hGluD2.

a, GSFSC curves for each whole and local map. Black line is Fourier shell correlation FSC = 0.143. Y axis is FSC, X is resolution in Å. b, Heat maps of particle orientation distribution for each map. c, Local resolution maps computed for each voxel, computed FSC = 0.143. d, Comparison of hGluD2 to hGluD2_{R710W-apo-closed}. e, Mutations compiled and reported in Ref. ³⁸ mapped onto hGluD2. Insets are areas of interest highlighted in panels f-h. f, Mutations that occur at the hGluD2 channel gate. g, Mutations that occur in the ATD region that coordinates the LBD layer. h, Mutations that occur in the front-to-back LBD dimer interface.