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. 2025 Sep 16;647(8091):1063–1071. doi: 10.1038/s41586-025-09610-x

Fig. 4. Activation mechanism.

Fig. 4

a, Activated hGluD2 with the apo hGluD2 overlaid in grey. b, Magnified view of the local A–B ATD dimer and the rigid body conformational change between states. c, How d-serine induces clamshell closure in the activated state compared to the apo state. d, Change in the ATD orchestration of the LBD layer upon activation by d-serine. e, The formation of the D–C LBD dimer that orchestrates activation. f, Top-down view of the resting (left) and activated (right) ion channel pore.