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. 2025 Sep 16;647(8091):1063–1071. doi: 10.1038/s41586-025-09610-x

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Extended Data Fig. 4 — a, Comparison of the A-B subunit local ATD dimer in hGluD2 with isolated local ATD dimer crystal structures from GluD1 and GluD2. b, Apo hGluD2 LBD comparison with apo GluD1 and GluD2 isolated LBD crystal structures. c, D-serine bound hGluD2 LBD compared to crystal structures of GluD1 and GluD2 isolated LBDs. d, Crystal structure of a back-to-back GluD2 LBD dimer. e, How the back-to-back LBD dimer would fit into hGluD2. f, Comparison of rat GluD2 ECD to hGluD2. f, Alignment of the Cbln1-GluD2 ATD crystal structure onto hGluD2. h, Comparison of hGluD2_ΔATD to an AMPAR LBD-TMD structure.