Fig. 2. The TRIM protein family. (A) Schematic representation of the TRIM proteins identified in the screen described in Figure 1. Color coding is as follows: red squares, RING domain; light blue squares, B-box type 1 domain; dark blue squares, B-box type 2 domain; marine blue squares, B-box of TRIM alternatively spliced isoforms not following type 1 or 2 criteria; green rectangles, CC region; orange rectangles, NHL repeats domain; yellow rectangles, RFP-like domain regions; brown squares, TSS domain; purple squares, PHD domain; magenta rectangles, bromodomain; black squares, ARF domain. (B) Alignments of the RING, the B-box type 1 and the B-box type 2 domains. The consensus sequences are indicated above. Conserved and similar amino acids are boxed. TRIM9, 24 and 36 double backslashes indicate a discontinuity in the sequence. Abbreviations are as in Figure 1. R, B1 and B2 consensi were built with 33, 14 and 35 mammalian sequences, respectively. Orthologous sequences were omitted for obvious reasons. Please note that TRIM37 in the R domain and TRIM19 and 23 in the B2 domain do not respect the spacing between conserved residues.