Table II. Comparison of the responses to Epo of 2fTGH cells stably expressing the chimeric receptors with those induced through the endogenous receptors by IFN-γ and IL-6.

Receptor	Ligand	JAK activationa	STAT1 activation	IRF-1 mRNA	IFN-γ-inducible mRNAs	Class II HLAb	Antiviral response
Eg	Epo	+	+ (T)c	+ (T)c	–	–	–
EgΔB	Epo	+	–d	–	–	–	–
EgΔBY440	Epo	+	+	+	+	+	+
EgΔBY905	Epo	+	+	+	+	+	+
IFN-γ	IFN-γ	+	+	+	+	+	+
IL-6	IL-6	+	+ (T)c	+ (T)c	–	–	–

^aJAKs1 and 2 for IFN-γ and JAKs1, 2 and Tyk2 for remainder.

^bmRNA (RNase protection) for all receptors and cell surface protein (FACS) for EgΔBY440/905, IFN-γ and IL-6.

^c (T), transient.

^dBarely detectable by EMSA.