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. 2025 Jun 25;111(10):6755–6761. doi: 10.1097/JS9.0000000000002846

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Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Figure 3. — KCTD9 overexpression enhances the efficacy of immunotherapy. (A). Gene Ontology pathway enrichment analysis revealed significant enrichment of pathways (PD-1 plus KCTD9-OE vs PD-1). (B and C) GSEA demonstrated the enrichment of gene sets associated with CD8⁺ T-cell activation and differentiation (PD-1 plus KCTD9-OE vs PD-1). (D) GSEA revealed an enrichment of gene sets related to the intestinal immune network (PD-1 plus KCTD9-OE group). (E) GSEA indicated an enrichment of gene sets unrelated to the intestinal immune network (PD-1 monotherapy group).