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. 2025 Oct 2;12:1609295. doi: 10.3389/fcvm.2025.1609295

Table 3.

Cox proportional hazard ratios for all cause mortality in patients with VTE.

Categories Model 1 Model 2 Model 3
HR (95 CI) P value P for trend HR (95 CI) P value P for trend HR (95 CI) P value P for trend
30-day mortality
LAR (Continuous) 1.41 (1.33–1.50) <0.001 1.29 (1.19–1.40) <0.001 1.18 (1.08–1.28) <0.001
LAR (Quartile) <0.001 <0.001 <0.001
Q1 (LAR <0.42)
Q2 (0.42 ≤ LAR < 0.64) 1.62 (1.14–2.29) 0.007 1.47 (1.03–2.09) 0.034 1.47 (1.03–2.09) 0.033
Q3 (0.64 ≤ LAR < 1.09) 2.06 (1.47–2.87) <0.001 1.67 (1.19–2.36) 0.003 1.56 (1.11–2.21) 0.011
Q4 (LAR ≥ 1.09) 3.54 (2.57–4.85) <0.001 2.59 (1.84–3.65) <0.001 2.02 (1.42–2.88) <0.001
365-day mortality
LAR (Continuous) 1.41 (1.33–1.49) <0.001 1.30 (1.20–1.39) <0.001 1.18 (1.08–1.27) <0.001
LAR (Quartile) <0.001 <0.001 <0.001
Q1 (LAR <0.42)
Q2 (0.42 ≤ LAR < 0.64) 1.47 (1.07–2.12) 0.017 1.34 (0.98–1.85) 0.072 1.36 (0.99–1.87) 0.061
Q3 (0.64 ≤ LAR < 1.09) 1.90 (1.40–2.56) <0.001 1.56 (1.49–2.13) 0.005 1.45 (1.06–1.98) 0.02
Q4 (LAR ≥ 1.09) 3.20 (2.41–4.24) <0.001 2.36 (1.73–3.22) <0.001 1.83 (1.33–2.52) <0.001

Model 1: adjusted for none.

Model 2: adjusted for age, weight, gender, race, heart rate, SpO2, respiratory rate, hematocrit, hemoglobin, RBC, WBC, bilirubin, creatinine, BUN, PCO2, PH, INR, PT, PTT.

Model 3: adjusted for age, weight, gender, race, heart rate, SpO2, respiratory rate, hematocrit, hemoglobin, RBC, WBC, bilirubin, creatinine, BUN, PCO2, PH, INR, PT, PTT, SOFA, APS III, AKI, hyperlipidemia, heart failure, coronary heart disease, hypertension, malignant cancer, ventilation, CRRT.

SpO2, oxygen saturation; RBC, red blood cell; WBC, white blood cell; BUN, blood urea nitrogen; PCO2, partial pressure of carbon dioxide; PH, potential of hydrogen; INR, international normalized ratio; PT, prothrombin time; PTT, partial thromboplastin time; SOFA, sequential organ failure assessment; APS III, acute physiology score III; AKI, ccute kidney injury; CRRT, continuous renal replacement therapy.