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. 2025 Oct 2;16:1628347. doi: 10.3389/fphar.2025.1628347

TABLE 4.

Significance analysis of the characteristics of ADRS in severe ADRs.

Name Option ADRS Total Inspection method χ2 P
Hematologic Mucocutaneous system Digestive system Systemic damage Respiratory Cardiovascular system Other
Age <18 110 10 6 0 6 0 7 139 pearsonchi-square test 106.246 0.000***
19∼45 12 10 9 2 3 2 2 40
46∼65 61 36 15 15 6 8 9 150
66∼79 31 20 1 3 1 2 5 63
>80 3 5 0 1 1 1 5 16
Sex Male 66 36 14 1 2 5 12 136 pearsonchi-square test 19.853 0.003***
Female 151 45 17 20 15 8 16 272
Classes of drugs Anti-tumor 201 4 18 5 4 0 6 238 pearsonchi-square test 366.906 0.000***
Anti-infectious agent 4 31 2 2 1 0 2 42
Circulating system drugs 2 3 4 0 2 4 2 17
Respiratory drugs 1 12 0 0 1 3 1 18
Blood system drugs 1 1 3 1 0 0 3 9
Other 8 30 4 13 9 6 14 84

* * *, * * *, and * represent 1%, 5%, and 10% significance levels, respectively.