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. 2025 Oct 2;17:1591946. doi: 10.3389/fnagi.2025.1591946

Figure 2.

Region-specific diCerentially expressed genes from parahippocampal gyrus (PHG), temporal cortex (TCX), superior temporalgyrus (STG), inferior frontal gyrus (IFG), dorsolateral prefrontal cortex(DLPFC), and cerebellum (CER) are shown as heat maps (A–F). Upregulatedgenes are displayed in red and downregulated genes in blue. The black bardenotes control samples, while the red bar denotes AD samples, illustratingdistinct expression patterns between groups.

Predictive gene expression signatures developed from region-specific DEGs. (A) PHG 176 gene signature (B) TCX 53 gene signature (C) STG 127 gene signature (D) IFG 44 gene signature (E) DLPFC 53 gene signature (F) CER 55 gene signature. The horizontal red bar represents AD samples, while the horizontal black bar represents control samples for each region. Genes are rows with upregulated expression shown in red, and downregulated expression in blue, with deeper colors indicating greater levels of upregulation or downregulation, respectively.