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. 2025 Oct 2;17:1591946. doi: 10.3389/fnagi.2025.1591946

Figure 3.

A three-panel figure showing (A) Upset plot showing overlapping genes across four or more regions, with vertical bars indicatingshared gene counts between region combinations and horizontal barsshowing individual region contributions. (B) CMAP analysis summary identifying 17 shared compounds across temporal cortex (TCX), superiortemporal gyrus (STG), inferior frontal gyrus (IFG) and dorsolateral prefrontalcortex (DLPFC) where larger, darker bubbles represent stronger reversal ofAD signatures. (C) Sankey plot mapping drug classes of the 17 compoundsalongside their CMAP-derived gene targets, illustrating therapeuticconnections across the four regions.

Signature gene analysis. (A) Upset plot displaying overlapping genes identified across four or more regions highlighting the number of genes shared between different combinations of regions. Vertical bars highlight the number of genes shared across the specified regions mentioned below, while horizontal bars represent how many genes from each individual region contribute to the overlapping gene sets. (B) Summary of CMAP analysis highlighting 17 compounds shared across TCX, STG, IFG, and DLPFC. Larger and darker blue bubbles indicate lower connectivity scores, representing a stronger reversal of the AD signature expression. (C) Sankey plot illustrating the drug class descriptions for the 17 shared compounds across TCX, STG, IFG, and DLPFC, along with their returned gene targets from CMAP.