Table 4.

Potentiation of cephalosporin antibiotics by phenyl urea adjuvants against MRSA ATCC BAA-1556 and AH-1263. All compounds tested at 60 μM. ABX denotes antibiotic alone.

Compound	Cefoxitin MIC (μg/mL) (fold reduction)		Cefotaxime MIC (μg/mL) (fold reduction)		Cephalothin MIC (μg/mL) (fold reduction)
	ATCC BAA-1556	AH-1263	ATCC BAA-1556	AH-1263	ATCC BAA-1556	AH-1263
ABX	32	32	32	32	4	4
1	32 (–)	32 (–)	16 (2)	16 (2)	4 (–)	1 (4)
2	8 (4)	8 (4)	16 (2)	16 (2)	1 (4)	0.5 (8)
4	16 (2)	16 (2)	16 (2)	16 (2)	1 (4)	2 (2)
7	16 (2)	16 (2)	16 (2)	16 (2)	4 (–)	2 (2)
9	16 (2)	8 (4)	16 (2)	16 (2)	1 (4)	1 (4)
14	16 (2)	8 (4)	16 (2)	16 (2)	0.5 (8)	0.25 (16)
19	16 (2)	16 (2)	16 (2)	16 (2)	1 (4)	2 (2)
21	8 (4)	8 (4)	8 (4)	8 (4)	0.5 (8)	0.5 (8)
28	32 (–)	32 (–)	32 (–)	32 (–)	2 (2)	4 (–)