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. 2025 Oct 3;13:1677422. doi: 10.3389/fbioe.2025.1677422

TABLE 8.

Application of DFSCs in bone tissue repair.

Cell type Material/scaffold Experimental model Experimental subject Results and conclusions References
DFSCs NAC Alveolar bone defect rat It has the potential to enhance the osteogenic differentiation ability. It enriches genes associated with the “developmental process”, decreases the intracellular ROS levels, and strengthens the antioxidant capacity Meng et al. (2022)
DFSCs HOTAIRM1 Skull defect rat Regulating the demethylation of H3K27 promotes osteogenic differentiation of DFSCs and shows stronger ALP activity and mineralized nodule formation ability under hypoxic conditions Chen et al. (2023)

DFSCs, Dental follicle stem cells; NAC, N-acetylcysteine; ROS, reactive oxygen species; ALP, alkaline phosphatase.