Table 3.
Notable associations between KLF4 and KLF5 and various obesity indices within the control (non-obese) group
| KLF4; Control (non-obese) | |||||||
|---|---|---|---|---|---|---|---|
| Original_KLF4 | Spearman | Normal_KLF4 | Pearson | ||||
| Variable | r | P-Val | Adj.P | Variable | r | P-Val | Adj.P |
| KLF5 | 0.718 | 0.000 | 0.005 | Normal_KLF5 | 0.652 | 0.001 | 0.021 |
| KLF4/KLF5 | 0.682 | 0.000 | 0.007 | Normal_KLF4/KLF5 | 0.640 | 0.001 | 0.021 |
| Amylase | 0.602 | 0.003 | 0.036 | Normal_BMI • | −0.562 | 0.007 | 0.078 |
| BMI • | −0.581 | 0.005 | 0.046 | Normal_BMI †‡₸ | −0.587 | 0.004 | 0.082 |
| BMI ‡ǂ | −0.165 | 0.462 | 0.816 | Normal_Iron • | −0.376 | 0.085 | 0.480 |
| AST • | −0.550 | 0.008 | 0.068 | Normal_Iron † | −0.554 | 0.007 | 0.089 |
| AST † | −0.287 | 0.195 | 0.638 | Normal_HOMAbeta | −0.548 | 0.008 | 0.125 |
| LDH | −0.466 | 0.029 | 0.217 | Amylase | 0.536 | 0.010 | 0.102 |
| HOMAbeta | −0.451 | 0.035 | 0.351 | Insulin | −0.501 | 0.018 | 0.176 |
| LDH | −0.457 | 0.032 | 0.253 | ||||
| Normal_AST | −0.454 | 0.034 | 0.253 | ||||
| KLF5; Control (non-obese) | |||||||
|---|---|---|---|---|---|---|---|
| Original_KLF5 | Spearman | Normal_KLF5 | Pearson | ||||
| Variable | r | P-Val | Adj.P | Variable | r | P-Val | Adj.P |
| KLF4 | 0.718 | 0.000 | 0.005 | Normal_KLF4 | 0.652 | 0.001 | 0.030 |
| KLF4/KLF5 | −0.639 | 0.001 | 0.027 | Normal_KLF4/KLF5 | −0.552 | 0.008 | 0.155 |
| CK-MB | −0.596 | 0.003 | 0.068 | CK-MB | −0.531 | 0.011 | 0.219 |
| BAI | 0.505 | 0.017 | 0.248 | TIBC | 0.493 | 0.020 | 0.296 |
| TIBC | 0.480 | 0.024 | 0.355 | Amylase | 0.456 | 0.033 | 0.409 |
| Weight • | −0.478 | 0.024 | 0.262 | ALP | 0.455 | 0.033 | 0.401 |
| Weight ‡ | −0.478 | 0.024 | 0.258 | normalWeight • | −0.448 | 0.037 | 0.409 |
| Amylase | 0.473 | 0.026 | 0.262 | normalWeight ‡ | −0.448 | 0.037 | 0.409 |
| sUA/sCr • | 0.462 | 0.031 | 0.367 | normalBMI †‡₸ | −0.435 | 0.043 | 0.397 |
| sUA/sCr ǂ | 0.389 | 0.074 | 0.706 | normalBMI • | −0.411 | 0.057 | 0.409 |
| BMI • | −0.429 | 0.046 | 0.312 | LDL-C | 0.411 | 0.057 | 0.409 |
| BMI ‡ǂ | −0.159 | 0.481 | 0.904 | ||||
| Iron | −0.428 | 0.047 | 0.312 | ||||
| ALP | 0.424 | 0.049 | 0.494 | ||||
KLF4 and KLF5 refer to Krüppel-like transcription factors 4 and 5, respectively
Original_KLF4 and Original_KLF5 denote raw, non-normalized expression values
Normal_KLF4 and Normal_KLF5 represent values normalized using a two-step transformation protocol [39]
Associations marked with • were unadjusted; †, ‡, ǂ, and ₸ indicate results adjusted for age, smoking status, AMH, and Normal_AMH, respectively
Notably, the association between Normal_KLF4 and Normal_Iron became statistically significant following adjustment for age