Table 4.

Notable associations between KLF4 and KLF5 with obesity indices in the obese cohort

KLF4; Obese
Original_KLF4	Spearman			Normal_KLF4	Pearson
Variable	r	P-Val	Adj.P	Variable	r	P-Val	Adj.P
KLF5	0.802	0.000	0.000	Normal_KLF5	0.767	0.000	0.000
HOMAIR	−0.622	0.001	0.035	Insulin	−0.586	0.003	0.077
Insulin	−0.582	0.003	0.047	Normal_KLF4/KLF5	0.563	0.004	0.077
KLF4/KLF5	0.577	0.003	0.047	HDL-C	0.552	0.005	0.077
HbA1c	−0.559	0.005	0.054	Normal_HOMAIR	−0.528	0.008	0.092
LDL-C	0.553	0.005	0.101	Normal_HbA1c	−0.520	0.009	0.092
HDL-C	0.523	0.009	0.088	Normal_CK	0.413	0.045	0.669
CK	0.521	0.009	0.136
TC	0.496	0.014	0.165
LDL-C/HDL-C	−0.434	0.034	0.293

KLF5; Obese
Original_KLF5	Spearman			Normal_KLF5	Pearson
Variable	r	P-Val	Adj.P	Variable	r	P-Val	Adj.P
KLF4	0.802	0.000	0.000	Normal_KLF4	0.767	0.000	0.000
KLF4/KLF5	−0.513	0.010	0.308	Normal_KLF4/KLF5	−0.533	0.007	0.182
Chloride •	0.488	0.016	0.312	FBS	−0.521	0.009	0.182
Chloride †	0.496	0.014	0.413	CK-MB	−0.428	0.037	0.554
HOMAIR	−0.432	0.035	0.362	Normal_BMI †‡₸	−0.417	0.042	0.364
CK-MB	−0.418	0.042	0.503	Normal_BMI •	−0.297	0.159	0.697
LDL-C	0.417	0.043	0.362	Normal_SBP •	−0.400	0.053	0.697
TC	0.415	0.044	0.362	Normal_SBP †	−0.384	0.064	0.770
WHR	0.414	0.044	0.362
HC	−0.407	0.048	0.362

KLF4 and KLF5 refer to Krüppel-like transcription factors 4 and 5, respectively

Original_KLF4 and Original_KLF5 denote unnormalized expression values, whereas Normal_KLF4 and Normal_KLF5 represent values normalized through a two-step transformation process [39]

Associations marked by • are unadjusted; †, ‡, ǂ, and ₸ indicate adjustment for age, smoking status, AMH, and Normal_AMH, respectively