Table 1.
Associations of sex-specific VAT quartiles with carotid wall volume (mm3) in the CAHHM cohort
| Carotid Wall Volume, mm3 in Visceral Adipose Quartiles | |||||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | P-trend | |
| Overall (N = 5546) | |||||
| N | 1428 | 1401 | 1397 | 1320 | |
| No fixed covariates | 897.6 (876.8, 918.4) | 907.4 (886.6, 928.2) | 907.0 (886.2, 927.9) | 917.8 (896.9, 938.8) | 0.003 |
| Minimally adjusted | 899.3 (877.7, 921.0) | 902.8 (881.2, 924.5) | 903.9 (882.3, 925.6) | 911.7 (890.0, 933.5) | 0.05 |
| + IHRS | 900.1 (878.7, 921.5) | 903.1 (881.8, 924.4) | 903.7 (882.4, 925.0) | 910.6 (889.0, 932.2) | 0.12 |
| +HFF | 899.5 (877.7, 921.3) | 902.8 (881.3, 924.4) | 903.9 (882.4, 925.4) | 911.4 (889.3, 933.5) | 0.12 |
| Minimal + IHRS without WHR | 900.1 (878.5, 921.7) | 903.6 (882.0, 925.1) | 904.6 (883.0, 926.2) | 912.4 (890.6, 934.2) | 0.06 |
| Females (N = 3054) | |||||
| N | 800 | 749 | 772 | 733 | |
| No fixed covariates | 837.4 (815.5, 859.2) | 843.8 (821.7, 865.8) | 844.8 (822.8, 866.8) | 848.1 (826.0, 870.2) | 0.14 |
| Minimally adjusted | 842.9 (821.3, 864.5) | 844.5 (822.8, 866.1) | 842.9 (821.3, 864.5) | 843.6 (821.9, 865.3) | 0.99 |
| + IHRS | 844.5 (822.8, 866.2) | 845.4 (823.7, 867.0) | 843.1 (821.6, 864.7) | 841.9 (819.9, 863.8) | 0.69 |
| +HFF | 843.6 (821.8, 865.4) | 844.9 (823.3, 866.5) | 843.5 (822.1, 865.0) | 843.7 (821.3, 866.1) | 0.97 |
| Minimal + IHRS without WHR | 844.0 (822.4, 865.6) | 845.1 (823.4, 866.7) | 843.1 (821.5, 864.6) | 842.5 (820.7, 864.4) | 0.80 |
| Males (N = 2492) | |||||
| N | 628 | 652 | 625 | 587 | |
| No fixed covariates | 966.6 (943.4, 989.9) | 973.3 (950.1, 996.4) | 977.0 (953.6, 1000) | 996.8 (973.0, 1021) | 0.003 |
| Minimally adjusted | 967.6 (945.2, 990.1) | 973.7 (951.6, 995.8) | 976.5 (954.2, 998.8) | 993.2 (970.5, 1016) | 0.01 |
| + IHRS | 968.0 (945.4, 990.6) | 973.8 (951.7, 995.8) | 976.2 (953.9, 998.6) | 992.6 (969.4, 1016) | 0.03 |
| +HFF | 967.3 (944.2, 990.5) | 973.4 (951.3, 995.5) | 976.4 (954.0, 998.7) | 993.1 (969.3, 1017) | 0.04 |
| Minimal + IHRS without WHR | 967.3 (944.7, 989.9) | 973.6 (951.4, 995.7) | 976.7 (954.3, 999.1) | 993.8 (970.7, 1017) | 0.01 |
Data within each cell are the adjusted least-squared means derived from a mixed model using all participants falling into that sex-specific quartile of VAT. Each mean and (95% confidence interval) is adjusted for the covariates presented in the first column. The minimally adjusted model contains a random effect for centre; as well as fixed effects for age and ethnicity. A linear contrast was used to assess the P-trend, using values of 1–4 across the quartiles. P- sex interaction > 0.28.
VAT visceral adipose tissue, IHRS INTERHEART Risk Score, HFF hepatic fat fraction, WHR waist-to-hip ratio.