Table 2.
Associations of sex specific HFF quartiles with carotid wall volume (mm3) in the CAHHM cohort
| Carotid Wall Volume, mm3 in Hepatic Fat Quartiles | |||||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | P-trend | |
| Overall (n = 5546) | |||||
| N | 1415 | 1388 | 1399 | 1344 | |
| No fixed covariates | 903.2 (882.9, 923.5) | 905.3 (884.9, 925.7) | 911.8 (891.5, 932.1) | 908.0 (887.6, 928.4) | 0.29 |
| Minimally adjusted | 903.3 (881.8, 924.8) | 900.6 (879.0, 922.1) | 908.4 (886.9, 929.8) | 905.2 (883.7, 926.7) | 0.45 |
| + IHRS | 904.0 (882.7, 925.3) | 901.2 (879.8, 922.5) | 908.0 (886.7, 929.3) | 903.3 (881.8, 924.8) | 0.81 |
| +VAT | 907.2 (885.4, 929.0) | 903.2 (881.4, 924.9) | 907.6 (886.0, 929.2) | 899.0 (876.9, 921.1) | 0.36 |
| Minimal + IHRS without WHR | 903.5 (882.1, 924.9) | 900.7 (879.3, 922.2) | 908.1 (886.8, 929.5) | 904.4 (882.8, 925.9) | 0.59 |
| Females (N = 3054) | |||||
| N | 791 | 758 | 777 | 728 | |
| No fixed covariates | 841.7 (820.1, 863.4) | 843.0 (821.2, 864.9) | 847.4 (825.7, 869.1) | 840.9 (819.1, 862.7) | 0.93 |
| Minimally adjusted | 845.2 (823.7, 866.8) | 843.6 (821.9, 865.3) | 845.9 (824.3, 867.5) | 839.9 (818.2, 861.6) | 0.54 |
| + IHRS | 846.1 (824.7, 867.4) | 844.6 (823.1, 866.1) | 845.9 (824.6, 867.2) | 837.7 (816.1, 859.3) | 0.30 |
| +VAT | 848.3 (826.7, 870.0) | 846.3 (824.5, 868.0) | 845.7 (824.3, 867.1) | 833.9 (811.5, 856.2) | 0.10 |
| Minimal + IHRS without WHR | 845.8 (824.4, 867.2) | 844.3 (822.7, 865.8) | 845.9 (824.5, 867.2) | 838.4 (816.7, 860.0) | 0.36 |
| Males (N = 2492) | |||||
| N | 624 | 630 | 622 | 616 | |
| No fixed covariates | 974.5 (952.2, 996.9) | 971.2 (948.8, 993.5) | 984.2 (962.0, 1007) | 980.1 (957.7, 1002) | 0.32 |
| Minimally adjusted | 973.7 (951.7, 995.6) | 970.1 (948.2, 992.0) | 983.5 (961.6, 1005) | 982.0 (960.0, 1004) | 0.19 |
| + IHRS | 974.5 (952.5, 996.6) | 970.7 (948.7, 992.6) | 982.9 (961.1, 1005) | 980.5 (958.2, 1003) | 0.34 |
| +VAT | 979.0 (956.0, 1002) | 972.9 (950.4, 995.5) | 982.1 (959.7, 1004) | 975.6 (952.2, 999.0) | 0.98 |
| Minimal + IHRS without WHR | 973.7 (951.7, 995.8) | 970.2 (948.2, 992.1) | 983.6 (961.7, 1005) | 982.1 (959.8, 1004) | 0.21 |
Data within each cell are the adjusted least-squared means derived from a mixed model using all participants falling into that sex-specific quartile of VAT. Each mean and (95% confidence interval) is adjusted for the covariates presented in the first column. The minimally adjusted model contains a random effect for centre; as well as fixed effects for age and ethnicity. A linear contrast was used to assess the P-trend, using values of 1–4 across the quartiles. P-sex interaction > 0.41.
VAT visceral adipose tissue, IHRS INTERHEART Risk Score, HFF hepatic fat fraction, WHR waist-to-hip ratio.