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. 2025 Oct 18;184(11):699. doi: 10.1007/s00431-025-06544-4

What is Known:

Existing neonatal hematologic reference intervals often lack stratification by gestational age and fetal growth.

This limits their utility in preterm and small-for-gestational-age infants, who have unique hematologic profiles due to distinct developmental trajectories and potential perinatal complications.

What is New:

This study establishes hematologic reference intervals stratified by gestational age and postnatal age specifically for preterm neonates.

It further highlights key differences between appropriate-for-gestational age and small-for-gestational age infants, improving the diagnostic accuracy for this vulnerable population.